Methanol → HCID 57879596, Verbindung

HRID 1673533Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1673533
CO.[CH2:3]([C:11]1[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[C:13]([NH:20][C:21](=[O:31])[CH2:22]/[CH:23]=[CH:24]/[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:12]=1)[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>[C].[Pd].C(OCC)(=O)C>[CH2:3]([C:11]1[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[C:13]([NH:20][C:21](=[O:31])[CH2:22][CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:12]=1)[CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Komponenten

5

Edukt 2

HCID 887MethanolHCID 57879390HCID 57879390, Verbindung

Produkt 1

HCID 57879596HCID 57879596, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

1.0 mg of 10% palladium-carbon was added to a mixed solution of 0.50 mL of methanol and 0.50 mL ethyl acetate containing 8.0 mg of 4-phenethyl-2-((E)-4-phenyl-3-butenamido)benzoic acid and stirred under hydrogen atmosphere at room temperature for 1 hour and 30 minutes. After insoluble were removed by filtration, the solvent was evaporated under reduced pressure and the obtained residue was purified with silica gel column chromatography [Flash Tube 2003 manufactured by Trikonex Company, eluent; ethyl acetate] to obtain 4.6 mg of 4-phenethyl-2-(4-phenylbutanamido)benzoic acid as white solid.

Aufarbeitung

  1. customAfter insoluble were removed by filtration
  2. customthe solvent was evaporated under reduced pressure
  3. customthe obtained residue was purified with silica gel column chromatography [Flash Tube 2003 manufactured by Trikonex Company, eluent; ethyl acetate]

Quellen und Nachweise

ORD-Eintrag
ord-d5a25b3642164447bb1f1a421ee64c3c
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07999132B2

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