1-(Bromomethyl)-2,3-difluoro-benzene → Ethyl 2-(2,3-difluorobenzyl)-3-oxobutyrate

HRID 1674156Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1674156
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[C:4]=1[F:10].[Na].[C:12]([O:18][CH2:19][CH3:20])(=[O:17])[CH2:13][C:14]([CH3:16])=[O:15]>O1CCCC1>[F:10][C:4]1[C:5]([F:9])=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][CH:13]([C:14](=[O:15])[CH3:16])[C:12]([O:18][CH2:19][CH3:20])=[O:17]

Komponenten

4

Edukt 2

HCID 5179841-(Bromomethyl)-2,3-difluoro-benzeneHCID 87089461Ethyl acetoacetatesodium salt

Produkt 1

HCID 57460769Ethyl 2-(2,3-difluorobenzyl)-3-oxobutyrateAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 1-(bromomethyl)-2,3-difluorobenzene (1.6 g) and ethyl acetoacetate sodium salt (2.36 g) in tetrahydrofuran (20 mL) was stirred for 12 hr. The insoluble material was filtered off, and the filtrate was concentrated. The residue was purified by silica gel column chromatography to give the title compound (1.56 g, 79%) as a colorless viscous oil.

Aufarbeitung

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-dc2356b681f2448abe1ec47d43d2b096
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07998968B2

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