Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.Cl[C:22]1[CH:23]=[CH:24][C:25]2[N:26]([C:28]([C:31]([F:34])([F:33])[F:32])=[N:29][N:30]=2)[N:27]=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:16][CH2:17][N:18]([C:22]3[CH:23]=[CH:24][C:25]4[N:26]([C:28]([C:31]([F:32])([F:34])[F:33])=[N:29][N:30]=4)[N:27]=3)[CH2:19][CH2:20]1)(=[O:13])=[O:14])[CH:6]=[CH:5]2Komponenten
3
Versuchsvorschrift
A mixture of 1-(6-bromonaphthalen-2-yl)sulfonylpiperazine and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 3. The crude product was purified by hplc using a Waters XTerra C18 column (5μ silica, 19 mm diameter, 100 mm length) eluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents to give 6-[4-(6-bromonaphthalen-2-yl)sulfonylpiperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine.
Aufarbeitung
- customto react by General Synthetic Method 3
- customThe crude product was purified by hplc
- washeluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents
Quellen und Nachweise
- ORD-Eintrag
- ord-404c69efdea6413cbe7a0b7ea4034c9c
- Quelldatensatz
- uspto-grants-2011_08
- Patentnummer
- US08003649B2
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