6-Chloro-3-(difluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine → 3-(Difluoromethyl)-6-[4-[1-(4-fluorophenyl)-1-methylethyl]piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazine

HRID 1674989Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1674989
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)([CH3:10])[CH3:9])=[CH:4][CH:3]=1.Cl[C:18]1[CH:19]=[CH:20][C:21]2[N:22]([C:24]([CH:27]([F:29])[F:28])=[N:25][N:26]=2)[N:23]=1>>[F:29][CH:27]([F:28])[C:24]1[N:22]2[N:23]=[C:18]([N:14]3[CH2:13][CH2:12][N:11]([C:8]([C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=4)([CH3:10])[CH3:9])[CH2:16][CH2:15]3)[CH:19]=[CH:20][C:21]2=[N:26][N:25]=1

Komponenten

3

Edukt 2

HCID 14723856-Chloro-3-(difluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazineHCID 673400631-[2-(4-Fluorophenyl)propan-2-yl]piperazine

Produkt 1

HCID 591497743-(Difluoromethyl)-6-[4-[1-(4-fluorophenyl)-1-methylethyl]piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazineAusbeute 62 %

Versuchsvorschrift

A mixture of 1-[1-(4-fluorophenyl)-1-methyl-ethyl]piperazine (obtained as described in J. Med. Chem. 2007, 50, 3528) and 6-chloro-3-(difluoromethyl)-[1,2,4]-triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 269 to give 3-(difluoromethyl)-6-[4-[1-(4-fluorophenyl)-1-methylethyl]piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazine in 62% yield.

Aufarbeitung

  1. customto react by an analogous method to Example 269

Quellen und Nachweise

ORD-Eintrag
ord-c152674489bc4e7f907c8a9367708fce
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08003649B2

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