Methyl iodide → 1-((1R,2S)-1-(ethoxycarbonyl)-2-vinylcyclopropyl-carbamoyl)-3-methyl-1H-imidazol-3-ium iodide

HRID 1675395Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1675395
[CH3:1][I:2].[N:3]1([C:8]([NH:10][C@:11]2([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:13][C@H:12]2[CH:14]=[CH2:15])=[O:9])[CH:7]=[CH:6][N:5]=[CH:4]1>C(#N)C>[I-:2].[CH2:19]([O:18][C:16]([C@@:11]1([NH:10][C:8]([N:3]2[CH:7]=[CH:6][N+:5]([CH3:1])=[CH:4]2)=[O:9])[CH2:13][C@H:12]1[CH:14]=[CH2:15])=[O:17])[CH3:20]

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 57816680(1R,2S)-ethyl 1-(1H-imidazole-1-carboxamido)-2-vinylcyclopropanecarboxylate

Produkt 1

HCID 866332061-((1R,2S)-1-(ethoxycarbonyl)-2-vinylcyclopropyl-carbamoyl)-3-methyl-1H-imidazol-3-ium iodide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Under nitrogen, methyl iodide (1.9 mL, 4 eq.) was added to a solution of compound 33 (2 g, 1 eq.) in ACN (16 mL). The reaction mixture was stirred at room temperature for 2 hrs. The solvent was removed under reduced pressure to yield compound 34 as yellow oil, which was used directly in the next step without further purification.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d7249a37462846cf819c763a58c5eacd
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08003659B2

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