Trifluoroacetic acid → 1-Ethynylcyclopropane-1-sulfonamide
Reaktionsgleichung
C([NH:8][S:9]([C:12]1([C:15]#[CH:16])[CH2:14][CH2:13]1)(=[O:11])=[O:10])(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:15]([C:12]1([S:9]([NH2:8])(=[O:11])=[O:10])[CH2:14][CH2:13]1)#[CH:16]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of compound 81 (200 mg, 0.81 mmol) and TFA (0.3 mL) in DCM (5 mL) was stirred at room temperature for 16 hrs. The reaction mixture was concentrated under reduced pressure and the crude material was purified by chromatography on silica gel (MeOH/DCM) to yield compound 82 in 70% yield.
Aufarbeitung
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe crude material was purified by chromatography on silica gel (MeOH/DCM)
Quellen und Nachweise
- ORD-Eintrag
- ord-a8325344332548a1a64e8bf36c3da0b4
- Quelldatensatz
- uspto-grants-2011_08
- Patentnummer
- US08003659B2
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