Hydrochloric Acid → 3-Methoxy-4-(prop-2-ynyloxy)benzoic acid

HRID 1675570Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1675570
[CH2:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]([C:9]([O:11]CC#C)=[O:10])=[CH:7][C:6]=1[O:17][CH3:18])[C:2]#[CH:3].[OH-].[Na+].Cl>CO>[CH2:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]=1[O:17][CH3:18])[C:2]#[CH:3]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 593017652-Propynyl 4-(2-propynyloxy)-3-methoxybenzoate

Produkt 1

HCID 131214803-Methoxy-4-(prop-2-ynyloxy)benzoic acidAusbeute 107,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To 50 ml of methanol were added 13.2 g of 2-propynyl 4-(2-propynyloxy)-3-methoxybenzoate and 40 ml of a 15% aqueous sodium hydroxide solution, and the resulting mixture was stirred at room temperature for 8 hours, and then at 50° C. for 2 hours. Thereafter, the reaction mixture which had been allowed to cool to near room temperature was added to hydrochloric acid to make the mixture acidic. The precipitated crystals were collected by filtration, and dried, and 12.0 g of 4-(2-propynyloxy)-3-methoxybenzoic acid was obtained.

Aufarbeitung

  1. waitat 50° C. for 2 hours
  2. temperatureto cool to near room temperature
  3. filtrationThe precipitated crystals were collected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-dadb5c4102d040e59fa5bc8703307617
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08003699B2

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