Toluene → 3,5-Difluoro-4-(2-propynyloxy)benzoyl chloride

Beteiligte Stoffe

Reaktionsschritte

To 17 ml of toluene were added 1.8 g of 3,5-difluoro-4-(2-propynyloxy)benzoic acid, 1 ml of thionyl chloride and 10 mg of DMF, and the resulting mixture was heated to reflux for 4 hours. Thereafter, the reaction mixture which had been allowed to cool to near room temperature was concentrated under reduced pressure, and 1.9 g of 3,5-difluoro-4-(2-propynyloxy)benzoyl chloride was obtained.

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