Hydrochloric Acid → 1-(2,2-Difluoroethyl)piperidin-4-amine Dihydrochloride
Reaktionsgleichung
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH:15]([F:17])[F:16])[CH2:10][CH2:9]1)(C)(C)C.[ClH:19]>O1CCOCC1>[ClH:19].[ClH:19].[F:17][CH:15]([F:16])[CH2:14][N:11]1[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a cooled (0 degrees) mixture of 1.21 g (4.58 mmole) of [1-(2,2-difluoro-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 20 mL of dioxane, was added 5.7 mL of 4M HCl in dioxane. The mixture was stirred at room temperature overnight, and the solid collected by filtration to give 0.90 g of 1-(2,2-difluoro-ethyl)-piperidin-4-ylamine dihydrochloride.
Aufarbeitung
- temperatureTo a cooled
- filtrationthe solid collected by filtration
Quellen und Nachweise
- ORD-Eintrag
- ord-e09a25ffa64343cc9ed69e9edec03e59
- Quelldatensatz
- uspto-grants-2011_08
- Patentnummer
- US08003785B2
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