Hydrochloric Acid → 1-(3-Methanesulfonyl-propyl)-piperidin-4-ylamine dihydrochloride

HRID 1676526Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1676526
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][S:17]([CH3:20])(=[O:19])=[O:18])[CH2:10][CH2:9]1)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[ClH:22].[CH3:20][S:17]([CH2:16][CH2:15][CH2:14][N:11]1[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]1)(=[O:19])=[O:18]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 67355480[1-(3-Methanesulfonyl-propyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Produkt 1

HCID 673553041-(3-Methanesulfonyl-propyl)-piperidin-4-ylamine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a cooled (0 degrees) mixture of 3.6 g (0.0113 mole) of [1-(3-methanesulfonyl-propyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 30 mL of dioxane, was added 14.1 mL of 4M HCl in dioxane. The mixture was stirred 18 hours at room temperature, and the solid collected by filtration to give 2.3 g of 1-(3-methanesulfonyl-propyl)-piperidin-4-ylamine dihydrochloride.

Aufarbeitung

  1. temperatureTo a cooled
  2. filtrationthe solid collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-7c4232b425dd4a1f8999d9e3ac9d02d4
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08003785B2

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