4-(Chlorosulfonyl)benzoic acid → 4-[3-(Methanesulfonyl)pyrrolidine-1-sulfonyl]benzoic acid
Reaktionsgleichung
Cl[S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH3:14][S:15]([CH:18]1[CH2:22][CH2:21][NH:20][CH2:19]1)(=[O:17])=[O:16]>>[CH3:14][S:15]([CH:18]1[CH2:22][CH2:21][N:20]([S:2]([C:5]2[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=2)(=[O:4])=[O:3])[CH2:19]1)(=[O:17])=[O:16]Komponenten
3
Versuchsvorschrift
The title intermediate is prepared from 4-(chlorosulfonyl)benzoic acid (CAS 10130-89-9) (375 mg, 1.7 mmol) and 3-(methylsulfonyl)pyrrolidine (CAS 433980-62-2) (343 mg, 2.3 mmol) in a manner substantially similar to Procedure F to provide 250 mg (44%) of the title compound. MS (ES−) 332.0 (M−H)−.
Quellen und Nachweise
- ORD-Eintrag
- ord-81b09e6f99174fd0a0c61c2c1e70c410
- Quelldatensatz
- uspto-grants-2011_08
- Patentnummer
- US08008296B2
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