1-Methylpiperazine → HCID 57571692, Verbindung
Reaktionsgleichung
C[C:2]1[C:3](Cl)=[N:4][C:5]([Cl:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[O:13]([C:20]1[CH:28]=[CH:27][C:23]([CH2:24][CH2:25][NH2:26])=[CH:22][CH:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[CH3:29][N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[Cl:11][C:5]1[N:4]=[C:3]([N:33]2[CH2:34][CH2:35][N:30]([CH3:29])[CH2:31][CH2:32]2)[CH:2]=[CH:10][C:6]=1[C:7]([NH:26][CH2:25][CH2:24][C:23]1[CH:22]=[CH:21][C:20]([O:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:28][CH:27]=1)=[O:9]Komponenten
4
Versuchsvorschrift
In analogy to example 21 methyl 2,6-dichloronicotinic acid was coupled with 4-phenoxyphenethylamine and then reacted with N-methylpiperazine. Yellow solid.
Quellen und Nachweise
- ORD-Eintrag
- ord-add8052afa2e4eea894782906d882f62
- Quelldatensatz
- uspto-grants-2011_08