1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → Ppl-100

HRID 1677215

Reaktionsgleichung

Reaktionsgleichung von HRID 1677215
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([C@H:16]([CH2:22][OH:23])[CH2:17][CH2:18][CH2:19][CH2:20][NH2:21])[CH2:12][CH:13]([CH3:15])[CH3:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH3:24][O:25][C:26]([NH:28][C@@H:29]([CH:33]([C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[C:30](O)=[O:31])=[O:27].C1C=CC2N(O)N=NC=2C=1.CCN=C=NCCCN(C)C>>[CH3:24][O:25][C:26](=[O:27])[NH:28][C@H:29]([C:30](=[O:31])[NH:21][CH2:20][CH2:19][CH2:18][CH2:17][C@H:16]([N:11]([S:8]([C:5]1[CH:6]=[CH:7][C:2]([NH2:1])=[CH:3][CH:4]=1)(=[O:10])=[O:9])[CH2:12][CH:13]([CH3:15])[CH3:14])[CH2:22][OH:23])[CH:33]([C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

Komponenten

5

Edukt 4

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 10017620(S)-2-methoxycarbonylamino-3,3-diphenyl-propionic acidHCID 20595420(1S)-4-amino-N-(5-amino-1-hydroxymethyl-pentyl)-N-isobutyl-benzenesulfonamide

Produkt 1

HCID 513956Ppl-100

Versuchsvorschrift

The title compound was prepared from (1S)-4-amino-N-(5-amino-1-hydroxymethyl-pentyl)-N-isobutyl-benzenesulfonamide (VII-deprotected) (step D) and (2S)-2-methoxycarbonylamino-3,3-diphenyl-propionic acid (step E) using the coupling procedure with HOBt and EDAC described in example 3 (step D). The final product was obtained in 67% yield (121 mg).

Quellen und Nachweise

ORD-Eintrag
ord-5f5783a0bff14d968a64b1f529746288
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08008297B2

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