HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Isopropoxybenzeneboronic acid → 1-[2-(3-Isopropoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Isopropoxybenzeneboronic acid | HCID 5083932 | — |
| Edukt | 1-(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one | HCID 57829218 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | 1-[2-(3-Isopropoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one | HCID 59540779 | — |
Reaktionsschritte
1-[2-(3-Isopropoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one was prepared starting from 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one and 3-Isopropoxybenzeneboronic acid following general procedures as described in these Examples. Silica gel chromatography using 30-70% EtOAc in hexanes as eluant provided 140 mg (82%) of a yellow solid. MP 149-150° C., M+H=338
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08008298B2 |
| Quelldatensatz | uspto-grants-2011_08 |
| ORD ID | ord-e4a254b6bfbf45b79848fa27222692ef |
| Quellennotiz | uspto-grants-2011_08 |