Sodium Hydroxide → 4-[5-(Tert-butoxycarbonylamino)-2-methyl-phenyl]benzoic acid

HRID 1678463Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1678463
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH:15]=[CH:14][C:13]=2[CH3:26])=[CH:8][CH:7]=1)=[O:5])C.[OH-].[Na+]>C(O)C>[C:22]([O:21][C:19]([NH:18][C:16]1[CH:15]=[CH:14][C:13]([CH3:26])=[C:12]([C:9]2[CH:8]=[CH:7][C:6]([C:4]([OH:5])=[O:3])=[CH:11][CH:10]=2)[CH:17]=1)=[O:20])([CH3:25])([CH3:24])[CH3:23]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 598223705'-tert-Butoxycarbonylamino-2'-methyl-biphenyl-4-carboxylic acid ethyl ester

Produkt 1

HCID 598223484-[5-(Tert-butoxycarbonylamino)-2-methyl-phenyl]benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

5′-tert-Butoxycarbonylamino-2′-methyl-biphenyl-4-carboxylic acid ethyl ester (6.3 g) was stirred in ethanol (75 ml) and 1M sodium hydroxide (30 ml) at 20 C for 18 h. The mixture was then acidified and the ethanol evaporated. The pale beige solid thus formed was collected by filtration and dried (4.26 g)

Aufarbeitung

  1. customthe ethanol evaporated
  2. customThe pale beige solid thus formed
  3. filtrationwas collected by filtration
  4. customdried (4.26 g)

Quellen und Nachweise

ORD-Eintrag
ord-b7aedf9efb6847d9a24fb4e5dd7c8d98
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08008303B2

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