Hydrochloric Acid → 5'-Amino-2'-chloro-biphenyl-4-carboxylic acid ethyl ester hydrochloride

HRID 1678486Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1678486
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:13]=2[Cl:21])=[CH:8][CH:7]=1)=[O:5])[CH3:2].Cl>C(O)C>[ClH:21].[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH2:18])[CH:15]=[CH:14][C:13]=2[Cl:21])=[CH:8][CH:7]=1)=[O:5])[CH3:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 598223932'-Chloro-5'-nitro-biphenyl-4-carboxylic acid ethyl ester

Produkt 1

HCID 673717565'-Amino-2'-chloro-biphenyl-4-carboxylic acid ethyl ester hydrochlorideAusbeute 192,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2′-Chloro-5′-nitro-biphenyl-4-carboxylic acid ethyl ester (1.04 g) in ethanol 30 ml) and 2M HCl (5.0 ml) was hydrogenated at RTP for 3 h. The mixture was then filtered through celite and the solvent evaporated to give the title compound as a dark red solid (1.02 g) which was used in the next stage without further purification.

Aufarbeitung

  1. filtrationThe mixture was then filtered through celite
  2. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-bc3e3e401b7e46ad99bced5cb28db57e
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08008303B2

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