5'-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2'-chloro-biphenyl-4-carboxylic acid ethyl ester → 5'-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2'-chloro-biphenyl-4-carboxylic acid

HRID 1678518Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1678518
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH:18][C:19](=[O:30])[CH2:20][N:21]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH3:22])[CH:15]=[CH:14][C:13]=2[Cl:31])=[CH:8][CH:7]=1)=[O:5])C>[OH-].[Na+].C(O)C>[C:26]([O:25][C:23]([N:21]([CH3:22])[CH2:20][C:19]([NH:18][C:16]1[CH:15]=[CH:14][C:13]([Cl:31])=[C:12]([C:9]2[CH:8]=[CH:7][C:6]([C:4]([OH:5])=[O:3])=[CH:11][CH:10]=2)[CH:17]=1)=[O:30])=[O:24])([CH3:29])([CH3:28])[CH3:27]

Komponenten

4

Edukt 1

HCID 673712285'-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2'-chloro-biphenyl-4-carboxylic acid ethyl ester

Produkt 1

HCID 673744955'-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2'-chloro-biphenyl-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

5′-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2′-chloro-biphenyl-4-carboxylic acid ethyl ester (494 mg) in 2M NaOH (10 ml) and ethanol (15 ml) was stirred at room temp for 18 h. The ethanol was then evaporated and the residue acidified with HCl. The colourless solid formed was collected by filtration and dried (420 mg).

Aufarbeitung

  1. customThe ethanol was then evaporated
  2. customThe colourless solid formed
  3. filtrationwas collected by filtration
  4. customdried (420 mg)

Quellen und Nachweise

ORD-Eintrag
ord-d8a6323c848a497ea91c5dbaaef6b134
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08008303B2

Notizen zur Reaktion

Wird geladen…