Hydrochloric Acid → 4-[3-(Hydroxymethyl)-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl]benzaldehyde

HRID 1678778Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1678778
[O:1]1CCO[CH:2]1[C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:20][C:19]3[C:18]4=[N:28][N:29]=[C:30]([CH2:31][OH:32])[N:17]4[CH:16]=[CH:15][C:14]=3[N:13]=2)=[CH:8][CH:7]=1.Cl>C1COCC1.C(OCC)(=O)C>[OH:32][CH2:31][C:30]1[N:17]2[C:18]([C:19]3[CH:20]=[C:21]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)[C:12]([C:9]4[CH:10]=[CH:11][C:6]([CH:2]=[O:1])=[CH:7][CH:8]=4)=[N:13][C:14]=3[CH:15]=[CH:16]2)=[N:28][N:29]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 59472958{8-[4-(1,3-Dioxolan-2-yl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-3-yl}methanol

Produkt 1

HCID 594728804-[3-(Hydroxymethyl)-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl]benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a suspension of 14-1 (2.1 g, 4.9 mMol) in THF (50 mL) was added 1N HCl (50 mL). After stirring at room temperature for 30 minutes, the reaction was diluted with ethyl acetate and washed twice with water, followed by brine. The organic layer was dried with MgSO4 and Na2SO4, filtered and concentrated in vacuo to yield 14-2 as a red solid. Mass (M+1) calculated: 381.1346 observed: 381.1346.

Aufarbeitung

  1. washwashed twice with water
  2. dry with materialThe organic layer was dried with MgSO4 and Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1264493ef6fb4777b70ebaa459783547
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08008317B2

Notizen zur Reaktion

Wird geladen…