Hydrochloric Acid → (5-Chloro-3-phenyl-1-benzofuran-2-yl)methanamine hydrochloride

HRID 1679676Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1679676
[C:1]([C:3]1[O:7][C:6]2[CH:8]=[CH:9][C:10]([Cl:12])=[CH:11][C:5]=2[C:4]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)#[N:2].B#B.Cl>O1CCCC1>[ClH:12].[NH2:2][CH2:1][C:3]1[O:7][C:6]2[CH:8]=[CH:9][C:10]([Cl:12])=[CH:11][C:5]=2[C:4]=1[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6328200DiboronHCID 227634675-Chloro-3-phenyl-1-benzofuran-2-carbonitrile

Produkt 1

HCID 22763506(5-Chloro-3-phenyl-1-benzofuran-2-yl)methanamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

Treat 2.0 g. of 2-cyano-5-chloro-3-phenylbenzo[b]furan (0.008 mole) in 30 ml. of tetrahydrofuran with 18 ml. of diborane in tetrahydrofuran (1 M solution) and reflux for 2 hours. Cool, add 10 ml. of 10% hydrochloric acid and reflux for 1/2 hour. Evaporate the solution to dryness and dissolve the residue in 50 ml. of ethanol. Add 30 ml. of ethanol saturated with hydrogen chloride. Dry the precipitate obtained to yield the title compound; m.p. 254°-256°.

Aufarbeitung

  1. additionTreat 2.0 g
  2. temperatureCool
  3. additionadd 10 ml
  4. customEvaporate the solution to dryness
  5. dissolutiondissolve the residue in 50 ml
  6. additionAdd 30 ml
  7. customDry the precipitate
  8. customobtained

Quellen und Nachweise

ORD-Eintrag
ord-cf457f7b0ccc4728ac007292c0efcc4d
Quelldatensatz
uspto-grants-1978_03
Patentnummer
US04081549

Notizen zur Reaktion

Wird geladen…