Sodium hydride → HCID 20361951, Verbindung

HRID 1679759Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1679759
[CH3:1][C:2]1[N:3]=[N:4][C:5](=[O:9])[C:6]=1[CH2:7][CH3:8].[H-].[Na+].[CH3:12][CH:13](Cl)[C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=1>CN(C)C=O>[CH3:1][C:2]1[NH:3][N:4]([CH:13]([CH3:12])[C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=2)[C:5](=[O:9])[C:6]=1[CH2:7][CH3:8]

Komponenten

5

Edukt 3

HCID 24758Sodium hydrideHCID 1082961,2-Dichloro-4-(1-chloroethyl)benzeneHCID 54312548HCID 54312548, Verbindung

Produkt 1

HCID 20361951HCID 20361951, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

25.2 g of 3-methyl-4-ethylpyrazol-5-one were added in portions to a suspension of 10.0 g (0.22 mol) of sodium hydride in 200 ml of absolute dimethylformamide. After the evolution of H2 had ceased, 41.8 g (0.2 mol) of α-methyl-3,4-dichlorobenzyl chloride were added dropwise to the reaction solution. The mixture was then stirred for 2 hours at 60° C, the solvent was distilled off in vacuo and the residue was taken up in water and acidified with dilute acetic acid. The crude product thereby obtained was recrystallized from ethanol.

Aufarbeitung

  1. distillationthe solvent was distilled off in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d82d97cff80a4683ba038232080c7cc8
Quelldatensatz
uspto-grants-1978_03
Patentnummer
US04081596

Notizen zur Reaktion

Wird geladen…