Ethyl Acetoacetate → Butanoic acid, 3-[[5-(acetylamino)-2-methoxyphenyl]amino]-, ethyl ester

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Reaktionsschritte

A mixture of 105.0 g (0.5 mole) of 2-nitro-4-acetamidoanisole, 67.0 g (0.5 mole) of ethyl acetoacetate, 550 ml of isopropyl alcohol, 10.0 g of 5% Pt/C, and 3.0 g of p-toluenesulfonic acid is treated in an autoclave at 165° C. with 1,000 psi of hydrogen until the uptake of hydrogen ceases. The solvent and catalyst are removed. Upon standing, 143.8 g (98%) of ethyl 3-(2'-methoxy-5-acetamidophenylamino)butyrate is obtained.

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