Hydrochloric Acid → HCID 70574841, Verbindung

HRID 1680014Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1680014
[ClH:1].[NH2:2][CH:3]([CH:11]1[NH:15][CH:14]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[C:13]2([CH2:30][CH2:29][N:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:27][CH2:26]2)[S:12]1)[C:4]([O:6]C(C)(C)C)=[O:5]>[N+](C)([O-])=O>[ClH:1].[ClH:1].[NH2:2][CH:3]([CH:11]1[NH:15][CH:14]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[C:13]2([CH2:26][CH2:27][N:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:29][CH2:30]2)[S:12]1)[C:4]([OH:6])=[O:5]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 23458748HCID 23458748, Verbindung

Produkt 1

HCID 70574841HCID 70574841, VerbindungAusbeute 95,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6375NitromethaneLösungsmittel

Versuchsvorschrift

A stream of gaseous hydrogen chloride is passed through a suspension of 11 g (0.0206 mole) of tert-butyl alpha-amino-4-benzyloxycarbonyl-8-phenyl-1-thia-3,8-diazaspiro[4.5]decane-2-acetate (obtained in 4.3) in 200 ml of nitromethane. After 1 hour, a clear solution is obtained which is filtered through "Hyflocel" and the filtrate is evaporated to dryness. The residue is taken up in diethyl ether, filtered and washed with diethyl ether. There are obtained 9.4 g of alpha-amino-4-benzyloxycarbonyl-8-phenyl-1-thia-3,8-diazaspiro[4.5]decane-2-acetic acid dihydrochloride. Yield: 95.5%; M.P. 164°-167° C. (decomposition).

Aufarbeitung

  1. customa clear solution is obtained which
  2. filtrationis filtered through "Hyflocel"
  3. customthe filtrate is evaporated to dryness
  4. filtrationfiltered
  5. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-32495cf419ef4049971c87f55029ec50
Quelldatensatz
uspto-grants-1981_06
Patentnummer
US04271172

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