Z-Lys(Boc)-ONp → Z-Lys(Boc)-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OtBu

HRID 1680054Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1680054
[CH3:1][C:2]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C@H:13]([NH:26][C:27]([O:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:28])[C:14]([O:16]C1C=CC([N+]([O-])=O)=CC=1)=O)=[O:7])([CH3:4])[CH3:3].[NH2:37][C@H:38]([C:41]([NH:43][C@H:44]([C:50]([NH:52][C@H:53]([C:57]([N:59]1[CH2:100][CH2:99][CH2:98][C@H:60]1[C:61]([NH:63][C@H:64]([C:69]([NH:71][C@H:72]([C:76]([NH:78][C@H:79]([C:83]([NH:85][C@H:86]([C:91]([O:93][C:94]([CH3:97])([CH3:96])[CH3:95])=[O:92])[CH2:87][CH:88]([CH3:90])[CH3:89])=[O:84])[C@@H:80]([CH3:82])[OH:81])=[O:77])[CH:73]([CH3:75])[CH3:74])=[O:70])[CH2:65][CH:66]([CH3:68])[CH3:67])=[O:62])=[O:58])[C@@H:54]([CH3:56])[OH:55])=[O:51])[CH2:45][CH2:46][C:47](=[O:49])[NH2:48])=[O:42])[CH2:39][OH:40]>CN(C=O)C>[NH:26]([C:27]([O:29][CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)=[O:28])[C@H:13]([C:14]([NH:37][C@H:38]([C:41]([NH:43][C@H:44]([C:50]([NH:52][C@H:53]([C:57]([N:59]1[CH2:100][CH2:99][CH2:98][C@H:60]1[C:61]([NH:63][C@H:64]([C:69]([NH:71][C@H:72]([C:76]([NH:78][C@H:79]([C:83]([NH:85][C@H:86]([C:91]([O:93][C:94]([CH3:96])([CH3:95])[CH3:97])=[O:92])[CH2:87][CH:88]([CH3:89])[CH3:90])=[O:84])[C@@H:80]([CH3:82])[OH:81])=[O:77])[CH:73]([CH3:74])[CH3:75])=[O:70])[CH2:65][CH:66]([CH3:67])[CH3:68])=[O:62])=[O:58])[C@@H:54]([CH3:56])[OH:55])=[O:51])[CH2:45][CH2:46][C:47](=[O:49])[NH2:48])=[O:42])[CH2:39][OH:40])=[O:16])[CH2:12][CH2:11][CH2:10][CH2:9][NH:8][C:6]([O:5][C:2]([CH3:1])([CH3:3])[CH3:4])=[O:7]

Komponenten

4

Edukt 2

HCID 13503265Z-Lys(Boc)-ONpHCID 131712256H-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OtBu

Produkt 1

HCID 131712255Z-Lys(Boc)-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OtBu

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

1.35 g Z-Lys(Boc)-ONp (2.7 mmol) and 2.42 g (2.64 mmol) H-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OtBu (F. 1) are dissolved in 35 ml DMF. After stirring at room temperature for 18 hours the reaction mixture is evaporated to dryness.

Aufarbeitung

  1. customis evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-09eca54661dc45849e6068ba366ff1f2
Quelldatensatz
uspto-grants-1981_06
Patentnummer
US04271152

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