Hydrochloric Acid → HCID 23457161, Verbindung

HRID 1680152Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1680152
[Cl:1][C:2]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:3]=1[NH:4][C:5]1[C:6]([CH2:10]O)=[CH:7][S:8][CH:9]=1.[ClH:17]>>[Cl:1][C:2]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:3]=1[NH:4][C:5]1[C:6]([CH2:10][Cl:17])=[CH:7][S:8][CH:9]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 234571594-(2,6-Dichloroanilino)-3-thiophenemethanol

Produkt 1

HCID 23457161HCID 23457161, Verbindung

Versuchsvorschrift

27.4 g (0.1 mole) of 4-(2,6-dichloroanilino)-3-thiophenmethanol are dissolved in 800 ml of concentrated aqueous hydrochloric acid, and the solution is left to stand for eight hours, poured onto ice and extracted with toluene. The organic phase is washed with sodium bicarbonate solution, dried and concentrated. Recrystallization of the residue from petroleum ether gives 3-(2,6-dichloroanilino)-4-chloromethylthiophen (m. 89° to 92°).

Aufarbeitung

  1. waitthe solution is left
  2. additionpoured onto ice
  3. extractionextracted with toluene
  4. washThe organic phase is washed with sodium bicarbonate solution
  5. customdried
  6. concentrationconcentrated
  7. customRecrystallization of the residue from petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-16231ea2333b4d1b814177caa6dbfbce
Quelldatensatz
uspto-grants-1981_06
Patentnummer
US04272507

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