Hydrochloric Acid → O-methyl homoserine methyl ester hydrochloride

HRID 1680594Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1680594
[CH3:1][O:2][CH2:3][CH2:4][C@@H:5]([C:7]([OH:9])=[O:8])[NH2:6].[ClH:10].[CH3:11]O>O1CCOCC1>[ClH:10].[CH3:11][O:8][C:7](=[O:9])[C@H:5]([CH2:4][CH2:3][O:2][CH3:1])[NH2:6]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 447570(S)-2-amino-4-methoxybutanoic acid

Produkt 1

HCID 86737808O-methyl homoserine methyl ester hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of 13.3 g of O-methyl homoserine in 370 ml of methanol and 180 ml of a 6 N solution of hydrogen chloride in dioxane is allowed to stand at room temperature for 3 to 4 days. The solvent is removed under reduced pressure and the residue lyophilized to give O-methyl homoserine methyl ester hydrochloride which is represented by the following formula ##STR51## Substitution of an equivalent quantity of O-methyl homoserine methyl ester hydrochloride for the methyl D-methioninate hydrochloride of Example 35 and substantial repetition of the procedures described in Examples 35 through 39 provides methyl DL-2,6-dimethyltyrosyl-DL-O-methylhomoseryl-glycyl-L-phenylalanyl-3-amino-1-adamantanecarboxylate hydrochloride which is represented by the following formula ##STR52##

Aufarbeitung

  1. customThe solvent is removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-086fd2fd23d74d2ea8e3c8cd67d5a83c
Quelldatensatz
uspto-grants-1981_06
Patentnummer
US04273704

Notizen zur Reaktion

Wird geladen…