Thionyl Chloride → 2-(Pentyloxy)propanoyl chloride
Reaktionsgleichung
[CH2:1]([O:6][CH:7]([CH3:11])[C:8](O)=[O:9])[CH2:2][CH2:3][CH2:4][CH3:5].S(Cl)([Cl:14])=O>>[CH2:1]([O:6][CH:7]([CH3:11])[C:8]([Cl:14])=[O:9])[CH2:2][CH2:3][CH2:4][CH3:5]Komponenten
3
Versuchsvorschrift
10 ml of thionyl chloride was added to 2.0 g of α-pentyloxypropionic acid and the mixture was refluxed under heat for 2 hours. Excess of thionyl chloride was distilled off to obtain α-pentyloxypropionic acid chloride. 20 ml of dry pyridine was added thereto, and 7.0 g of 5-decyl-2-(4-hydroxyphenyl)pyrimidine dissolved in 50 ml of dry benzene was further added dropwise. After the addition, the mixture was refluxed under heat, charged into ice water and extracted with benzene. The extract was purified with a silica gel column chromatography to obtain 5-decyl-2-(4'-α-pentyloxypropanoyloxyphenyl)pyrimidine.
Aufarbeitung
- temperaturethe mixture was refluxed
- temperatureunder heat for 2 hours
- distillationExcess of thionyl chloride was distilled off
Quellen und Nachweise
- ORD-Eintrag
- ord-42f49132c34a4c5da4579dbb26b56e05
- Quelldatensatz
- uspto-grants-1992_12
- Patentnummer
- US05167857
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