Reaktionsgleichung
[C:1]([O-:15])(=[O:14])[CH2:2][CH2:3][NH:4][C:5](=[O:13])[C@@H:6]([C:8]([CH2:11][OH:12])([CH3:10])[CH3:9])[OH:7].[Ca+2].[C:17]([O-])(=O)[CH2:18][CH2:19]NC(=O)[C@@H](C(CO)(C)C)O.F[C:33](F)(F)C(O)=O.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O.COC(OC)(C)C>[CH3:33][O:14][C:1](=[O:15])[CH2:2][CH2:3][NH:4][C:5]([CH:6]1[C:8]([CH3:10])([CH3:9])[CH2:11][O:12][C:18]([CH3:19])([CH3:17])[O:7]1)=[O:13]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A 5.0 g portion of calcium pantothenate was slurred in 100 ml of acetone:2,2-dimethoxypropane (1:1). Trifluoroacetic acid (3.0 ml) was added until solution was complete and stirring was continued overnight. A 10 g portion of potassium carbonate was added, this mixture stirred vigorously for 10 minutes and then concentrated to a gummy solid. A 100 ml portion of acetonitrile and 10 ml of methyl iodide were added to the solid. This mixture was stirred for 1 day, then poured into water and extracted twice with ethyl acetate. The extracts were combined, dried and concentrated, giving 4.8 g of the desired compound as a yellow oil.
Aufarbeitung
- stirringthis mixture stirred vigorously for 10 minutes
- concentrationconcentrated to a gummy solid
- additionA 100 ml portion of acetonitrile and 10 ml of methyl iodide were added to the solid
- stirringThis mixture was stirred for 1 day
- additionpoured into water
- extractionextracted twice with ethyl acetate
- customdried
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-b67c518b1e79424d86b3ab7c282bc5d3
- Quelldatensatz
- uspto-grants-1992_12
- Patentnummer
- US05173510
Verknüpfte Notizen
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