Potassium Hydroxide → 99517-24-5

HRID 1681858Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1681858
[C:1]([C:5]1[C:10]2[O:11][CH:12]=[CH:13][C:9]=2[CH:8]=[C:7]([Cl:14])[CH:6]=1)([O:3]C)=[O:2].[OH-].[K+]>CO>[Cl:14][C:7]1[CH:6]=[C:5]([C:1]([OH:3])=[O:2])[C:10]2[O:11][CH:12]=[CH:13][C:9]=2[CH:8]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 14838646HCID 14838646, Verbindung

Produkt 1

HCID 1483864799517-24-5Ausbeute 94,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 7-carbomethoxy-5-chlorobenzo[b]furan (6c) (3.02 g, 14.3 mmol) containing potassium hydroxide (3.22 g) in 100 ml of aqueous methanol (CH3OH/H2O=3/2) was stirred at room temperature overnight. The mixture was concentrated under reduced pressure. The residue was acidified with conc. HCl to pH of about 1, cooled in freezer for several hours and filtered to give 7c as an off-white solid (2.65 g, 94.3%), mp 212°-215° C. NMR (DMSO-d6) δ8.0-6.87 (m, 5H, aromatic protons and OH).

Aufarbeitung

  1. concentrationThe mixture was concentrated under reduced pressure
  2. temperaturecooled in freezer for several hours
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-79da8bb4341746ca9fc90baff57ee9e6
Quelldatensatz
uspto-grants-1992_12
Patentnummer
US05175173

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