Benzoyl chloride → N-benzoyl-5-methylindole

HRID 1681931

Reaktionsgleichung

[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[C:11](Cl)(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[C:11]([N:7]1[C:8]2[C:4](=[CH:3][C:2]([CH3:1])=[CH:10][CH:9]=2)[CH:5]=[CH:6]1)(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Komponenten

Edukt 2

HCID 7412Benzoyl chloride

HCID 119785-Methylindole

Produkt 1

HCID 10354051N-benzoyl-5-methylindole

Versuchsvorschrift

The 5-methylindole 1a is benzoylated with benzoyl chloride of a substituted benzoic acid to give N-benzoyl-5-methylindole, 1b. The bromination of 1b with N-bromosuccinimide and a catalytic amount of azobisisobutyronitrile in refluxing carbon tetrachloride affords N-benzoyl-5-bromomethylindole, 1c. ##STR43##

Quellen und Nachweise

ORD-Eintrag: ord-6d2be8c6d7124e37b45dd064bf8ab7c8
Quelldatensatz: uspto-grants-1992_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05175164

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