Ethyl Acetate → methyl 5-formyl-(R)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-pentanecarboxylate

HRID 1681971

Reaktionsgleichung

Reaktionsgleichung von HRID 1681971
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][C@H:8]([CH2:14][CH2:15][CH:16]=C)[CH2:9][C:10](OC)=O.[O:18]=[O+][O-].[H][H].[C:23]([O:26][CH2:27]C)(=[O:25])C>>[CH:16]([CH2:15][CH2:14][C@@H:8]([O:7][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][O:1]1)[CH2:9][CH2:10][C:23]([O:26][CH3:27])=[O:25])=[O:18]

Komponenten

5

Edukt 4

HCID 8857Ethyl AcetateHCID 24823OzoneHCID 86743990methyl (R)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-6-heptenoateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 86743989methyl 5-formyl-(R)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-pentanecarboxylate

Versuchsvorschrift

A solution of 2.56 g of methyl (R)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-6-heptenoate in 40 ml of ethyl acetate was treated with ozone at -75° C. After completion of the reaction 0.1 g of Pd-on-carbon was added thereto and the mixture was hydrogenated at room temperature. After the hydrogen uptake was finished the catalyst was filtered off and washed with ethyl acetate and the filtrate and washings were evaporated in vacuo There was obtained methyl 5-formyl-(R)-3-[(tetrahydro-2H-pyran-2- yl)oxy]-pentanecarboxylate.

Aufarbeitung

  1. additionwas added
  2. customwas hydrogenated at room temperature
  3. filtrationwas filtered off
  4. washwashed with ethyl acetate
  5. customthe filtrate and washings were evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d3eeb5bb118342bba91d9bd58bf0ef56
Quelldatensatz
uspto-grants-1992_12
Patentnummer
US05175186

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