Hydrochloric Acid → HCID 88508788, Verbindung
Reaktionsgleichung
[NH2:1][CH:2](/[CH:6]=[CH:7]/[CH2:8][P:9]([OH:12])([OH:11])=[O:10])[C:3]([OH:5])=[O:4].Cl>C(O)(CC)C>[CH:2]([O:4][C:3](=[O:5])[CH:2]([NH2:1])/[CH:6]=[CH:7]/[CH2:8][P:9]([OH:12])([OH:11])=[O:10])([CH2:6][CH3:7])[CH3:3]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
1.5 g of E-2-amino-5-phosphono-3-pentenoic acid are suspended in 30 ml of sec.-butanol and the suspension is saturated with hydrogen chloride gas for 4 hours at 75°. After concentration, the residue is dissolved in 10 ml of 2-butanol, 10 ml of propylene oxide are added and the precipitate is filtered off. Recrystallisation from water/acetone 1:1 yields E-2-amino-5-phosphono-3-pentenoic acid sec.-butyl ester, m.p. 169°-170°.
Aufarbeitung
- concentrationAfter concentration
- dissolutionthe residue is dissolved in 10 ml of 2-butanol
- addition10 ml of propylene oxide are added
- filtrationthe precipitate is filtered off
- customRecrystallisation from water/acetone 1:1
Quellen und Nachweise
- ORD-Eintrag
- ord-b03afb695bed43d39a4539aebc4b765d
- Quelldatensatz
- uspto-grants-1992_12
- Patentnummer
- US05175344
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