Benzoyl chloride, 3,4,5-trimethoxy- → 4-(3,4-Dichloro-phenyl)-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-2-one

HRID 1683082Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1683082
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:15][CH2:16][O:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][O:19]3)[CH2:13][NH:12][C:11](=[O:14])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH:32]=[C:33]([O:37][CH3:38])[C:34]=1[O:35][CH3:36])[C:29](Cl)=[O:30]>CN(C)C1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:15][CH2:16][O:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][O:19]3)[CH2:13][N:12]([C:29](=[O:30])[C:28]3[CH:27]=[C:26]([O:25][CH3:24])[C:34]([O:35][CH3:36])=[C:33]([O:37][CH3:38])[CH:32]=3)[C:11](=[O:14])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Komponenten

4

Edukt 2

HCID 78282Benzoyl chloride, 3,4,5-trimethoxy-HCID 211976714-(2-Tetrahydropyranyloxyethyl)-4-(3,4-dichlorophenyl)-2-pyrrolidone

Produkt 1

HCID 537998014-(3,4-Dichloro-phenyl)-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 949N,N-DimethylanilineLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

Combine 4-(3,4-dichloro-phenyl)-4-[2-(tetrahydro-pyran-2-yloxy)ethyl]-pyrrolidin-2-one (as prepared in example 11.3) (5 mmol) and 3,4,5-trimethoxy-benzoyl chloride (5.0 mmol) in N,N-dimethylaniline (20 mL). Heat to 90° C. and stir for 24 h. Concentrate in vacuo . Partition the reaction mixture between dichloromethane and H2O. Separate the organic layer, dry over MgSO4, filter, and concentrate in vacuo to obtain a residue. Purify to give the title compound.

Aufarbeitung

  1. concentrationConcentrate in vacuo
  2. customPartition the reaction mixture between dichloromethane and H2O
  3. customSeparate the organic layer
  4. dry with materialdry over MgSO4
  5. filtrationfilter
  6. concentrationconcentrate in vacuo
  7. customto obtain a residue
  8. customPurify

Quellen und Nachweise

ORD-Eintrag
ord-146fde8b8e4c4bdeb6434dcb32d2c965
Quelldatensatz
uspto-grants-1997_06
Patentnummer
US05635510

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