4-(3-Hydroxypropylamino)-3-nitropyridine → 3-Amino-4-(3-hydroxypropylamino)pyridine

HRID 1683178

Reaktionsgleichung

Reaktionsgleichung von HRID 1683178
[OH:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][C:7]=1[N+:12]([O-])=O>C(O)C.[Ni]>[NH2:12][C:7]1[CH:8]=[N:9][CH:10]=[CH:11][C:6]=1[NH:5][CH2:4][CH2:3][CH2:2][OH:1]

Komponenten

4

Edukt 1

HCID 5923304-(3-Hydroxypropylamino)-3-nitropyridine

Produkt 1

HCID 190429283-Amino-4-(3-hydroxypropylamino)pyridine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

4-(3-Hydroxypropylamino)-3-nitropyridine (4.12 g, 20.9 mmol) was dissolved in ethanol (130 ml) and Raney nickel (411 mg, 7.0 mmol) added. The stirred mixture was hydrogenated for 3 days. The catalyst was removed by filtration under argon and the solvent removed under reduced pressure to give 3-amino-4-(3- hydroxypropylamino)pyridine as a brown oil which was used directly in the next step.

Aufarbeitung

  1. customThe catalyst was removed by filtration under argon
  2. customthe solvent removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0b245cb559a94e40b09fed9cdc42702f
Quelldatensatz
uspto-grants-1997_06
Patentnummer
US05637595

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