N-bromobutanimide → 3,7-Dibromo-2,3-dihydro-2,2-dimethylbenzofuran

HRID 1683686

Reaktionsgleichung

Reaktionsgleichung von HRID 1683686
[Br:1][C:2]1[C:10]2[O:9][C:8]([CH3:12])([CH3:11])[CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[Br:13]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:13][CH:7]1[C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([Br:1])[C:10]=2[O:9][C:8]1([CH3:12])[CH3:11]

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 2720047-Bromo-2,2-dimethyl-2,3-dihydro-1-benzofuran

Produkt 1

HCID 190407783,7-Dibromo-2,3-dihydro-2,2-dimethylbenzofuran

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

A stirring mixture of 7.0 grams (0.031 mole) of 7-bromo-2,3-dihydro-2,2-dimethylbenzofuran and 5.5 grams (0.031 mole) of N-bromosuccinimide in 150 mL of carbon tetrachloride is heated to reflux while irradiating with a sun lamp. The refluxing reaction mixture is stirred for about three hours, then it is cooled to ambient temperature. After this time the reaction mixture is washed with two 50 mL portions of aqueous 5% sodium bicarbonate solution, and one 50 mL portion of water. The organic layer is dried with magnesium sulfate and filtered. The filtrate is concentrated under reduced pressure, yielding 3,7-dibromo-2,3-dihydro-2,2-dimethylbenzofuran.

Aufarbeitung

  1. temperatureis heated
  2. temperatureto reflux
  3. customwhile irradiating with a sun lamp
  4. customThe refluxing reaction mixture
  5. washAfter this time the reaction mixture is washed with two 50 mL portions of aqueous 5% sodium bicarbonate solution, and one 50 mL portion of water
  6. dry with materialThe organic layer is dried with magnesium sulfate
  7. filtrationfiltered
  8. concentrationThe filtrate is concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f9377cadf7c145cfbdf166638de5c4b4
Quelldatensatz
uspto-grants-1997_06
Patentnummer
US05639753

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