1-[2-(piperidin-1-yl)ethyl]-1H-benzimidazol-2-amine → 2-Amino-3-(5-bromo-2-thenoylmethyl)-1-(2-piperidinoethyl)-benzimidazole hydrobromide

Beteiligte Stoffe

Reaktionsschritte

Add a solution of 5-bromo-2-bromoacetylthiophene (5.68 g, 20 mmol) in 30 ml of ether to a hot solution of 2-amino-1-(2-piperidinoethyl)-benzimidazole (4.88 g, 20 mmol) in 150 ml of acetone. Stir and maintain at room temperature for five hours. Suction-filter the precipitate, wash with acetone and then with ether to obtain the title compound.

Herkunft & Nachweise