2,3-dihydro-6-methoxy-1H-isoindol-5-ol → alpha-(3,4-Dimethoxyphenyl)-1,3-dihydro-5-hydroxy-6-methoxy-alpha-[(4-methylphenyl)thio]-2H-isoindole-2-heptanenitrile

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2,3-dihydro-6-methoxy-1H-isoindol-5-ol	HCID 10241135	—
Edukt	alpha-(5-Bromopentyl)-3,4-dimethoxy-alpha-[(4-methylphenyl)thio]benzeneacetonitrile	HCID 10527448	—
Produkt	alpha-(3,4-Dimethoxyphenyl)-1,3-dihydro-5-hydroxy-6-methoxy-alpha-[(4-methylphenyl)thio]-2H-isoindole-2-heptanenitrile	HCID 10530307	74,2%

Reaktionsschritte

The procedure of Example 49 is used with 0.209 g of 2,3-dihydro-6-methoxy-1H-isoindol-5-ol (Example 105) and 0.57 g of α-(5-bromopentyl)-3,4- dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile. This affords 0.5 g of the desired product as a gray foam.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05639887
Quelldatensatz	uspto-grants-1997_06
ORD ID	ord-302529887b174f77aecaf6a1af026878
Quellennotiz	uspto-grants-1997_06