Methylamine → HCID 25052051, Verbindung

HRID 1685001Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1685001
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15]Cl)[N:14]=1)=[O:8].[CH3:21][NH2:22]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][NH:22][CH3:21])[N:14]=1)=[O:8]

Komponenten

3

Edukt 2

HCID 6329MethylamineHCID 58055096HCID 58055096, Verbindung

Produkt 1

HCID 25052051HCID 25052051, Verbindung

Versuchsvorschrift

A solution of 1-(3,4-dichlorobenzyl)-3-(4-(chloromethyl)thiazol-2-yl)urea and excess methylamine (2.0 M solution in tetrahydrofuran) was heated for 15 minutes at 60° C. under microwave irradiation. The volatiles were removed in vacuo and the product was purified by column chromatography (DCM/0-15% NH3 saturated MeOH) to afford the title compound.

Aufarbeitung

  1. customThe volatiles were removed in vacuo
  2. customthe product was purified by column chromatography (DCM/0-15% NH3 saturated MeOH)

Quellen und Nachweise

ORD-Eintrag
ord-b8f41a4f2ee14dbbaf9f52f75f90404d
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08148380B2

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