5-Formyl-3,4-dimethyl-thiophene-2-carboxylic acid → 3-(2-Ethyl-4-[5-(5-formyl-3,4-dimethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenyl}-propionic acid

HRID 1685743

Reaktionsgleichung

Reaktionsgleichung von HRID 1685743
[CH:1]([C:3]1[S:7][C:6]([C:8]([OH:10])=O)=[C:5]([CH3:11])[C:4]=1[CH3:12])=[O:2].[CH2:13]([C:15]1[CH:20]=[C:19]([C:21](=[NH:24])[NH:22]O)[CH:18]=[C:17]([CH3:25])[C:16]=1[CH2:26][CH2:27][C:28]([OH:30])=[O:29])[CH3:14]>>[CH2:13]([C:15]1[CH:20]=[C:19]([C:21]2[N:22]=[C:8]([C:6]3[S:7][C:3]([CH:1]=[O:2])=[C:4]([CH3:12])[C:5]=3[CH3:11])[O:10][N:24]=2)[CH:18]=[C:17]([CH3:25])[C:16]=1[CH2:26][CH2:27][C:28]([OH:30])=[O:29])[CH3:14]

Komponenten

3

Edukt 2

HCID 866464325-Formyl-3,4-dimethyl-thiophene-2-carboxylic acidHCID 178436623HCID 178436623, Verbindung

Produkt 1

HCID 866464473-(2-Ethyl-4-[5-(5-formyl-3,4-dimethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenyl}-propionic acid

Versuchsvorschrift

The title compound is prepared according to Method A starting from 5-formyl-3,4-dimethyl-thiophene-2-carboxylic acid and 3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid; LC-MS: tR=1.08 min; [M+1]+=399.05.

Quellen und Nachweise

ORD-Eintrag
ord-905999f8fb5b4fe1bfbf4ba93389bffd
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08148410B2

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