4-Ethyl-5-formyl-thiophene-2-carboxylic acid → N-((S)-3-(2-Ethyl-4-[5-(4-ethyl-5-formyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide

HRID 1685747

Reaktionsgleichung

Reaktionsgleichung von HRID 1685747
C(C1C=C(C(O)=O)SC=1C=O)C.[CH2:13]([C:15]1[CH:30]=[C:29]([C:31]2[N:35]=[C:34]([C:36]3[S:37][C:38]([CH:43]=[O:44])=[C:39]([CH3:42])[C:40]=3[CH3:41])[O:33][N:32]=2)[CH:28]=[C:27]([CH3:45])[C:16]=1[O:17][CH2:18][C@@H:19]([OH:26])[CH2:20][NH:21][C:22](=[O:25])[CH2:23][OH:24])[CH3:14]>>[CH2:13]([C:15]1[CH:30]=[C:29]([C:31]2[N:35]=[C:34]([C:36]3[S:37][C:38]([CH:43]=[O:44])=[C:39]([CH2:40][CH3:41])[CH:42]=3)[O:33][N:32]=2)[CH:28]=[C:27]([CH3:45])[C:16]=1[O:17][CH2:18][C@@H:19]([OH:26])[CH2:20][NH:21][C:22](=[O:25])[CH2:23][OH:24])[CH3:14]

Komponenten

3

Edukt 2

HCID 200677334-Ethyl-5-formyl-thiophene-2-carboxylic acidHCID 86646446N-((S)-3-{2-Ethyl-4-[5-(5-formyl-3,4-dimethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide

Produkt 1

HCID 86646451N-((S)-3-(2-Ethyl-4-[5-(4-ethyl-5-formyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide

Versuchsvorschrift

The title compound is prepared according to Method E starting from 4-ethyl-5-formyl-thiophene-2-carboxylic acid and N—((S)-3-{2-ethyl-4-[5-(5-formyl-3,4-dimethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide; LC-MS: tR=0.73 min; [M+1]+=474.20.

Quellen und Nachweise

ORD-Eintrag
ord-9a21bdb23fe04d12a898988bed3416fb
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08148410B2

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