Dimethylformamide → 3-Azido-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one

HRID 1687634Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1687634
I[CH:2]1[CH2:8][C:7]([CH3:10])([CH3:9])[C:6]2[CH:11]=[CH:12][C:13]([N+:15]([O-:17])=[O:16])=[CH:14][C:5]=2[NH:4][C:3]1=[O:18].[N-:19]=[N+:20]=[N-:21].[Na+].CN(C=O)C>>[N:19]([CH:2]1[CH2:8][C:7]([CH3:10])([CH3:9])[C:6]2[CH:11]=[CH:12][C:13]([N+:15]([O-:17])=[O:16])=[CH:14][C:5]=2[NH:4][C:3]1=[O:18])=[N+:20]=[N-:21]

Komponenten

4

Edukt 3

HCID 6228DimethylformamideHCID 33557Sodium AzideHCID 672643563-Iodo-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one

Produkt 1

HCID 866339913-Azido-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one

Versuchsvorschrift

3-Iodo-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one (5.367 g, 0.015 mol), Sodium azide (6.49 g, 0.1 mol), and DMF (100 mL, 2 mol) were stirred at rt for 2 h. The reaction mixture was diluted with H20 and the resulting beige ppt was filtered.

Aufarbeitung

  1. additionThe reaction mixture was diluted with H20
  2. filtrationthe resulting beige ppt was filtered

Quellen und Nachweise

ORD-Eintrag
ord-8f7adc16f7244274895898e7c92241f0
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08148391B2

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