Ammonium Chloride → 2-(3-(Diethoxymethyl)phenyl)ethanol

HRID 1689241Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1689241
[Cl-].[NH4+].[OH:3][CH2:4][CH2:5][C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)C=O.C(O[CH:17]([O:21][CH2:22][CH3:23])[O:18][CH2:19][CH3:20])C>CCO>[CH2:22]([O:21][CH:17]([O:18][CH2:19][CH3:20])[C:12]1[CH:13]=[C:6]([CH2:5][CH2:4][OH:3])[CH:7]=[CH:8][CH:11]=1)[CH3:23]

Komponenten

5

Edukt 3

HCID 25517Ammonium ChlorideHCID 31214Ethyl orthoformateHCID 184247323-(2-Hydroxyethyl)benzaldehyde

Produkt 1

HCID 579893032-(3-(Diethoxymethyl)phenyl)ethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

Ammonium chloride (0.08 g) was added to a solution of 3-(2-hydroxyethyl)benzaldehyde (example 20, step b) (0.45 g) and triethoxymethane (0.55 g) in EtOH (8 mL) and the reaction mixture heated at 70° C. for 3 h. After cooling, the reaction mixture was partitioned between ethyl acetate and saturated sodium bicarbonate solution. The ethyl acetate solution was dried over sodium sulphate, filtered and evaporated in vacuo to give the subtitled compound as a gum. Yield 0.24 g.

Aufarbeitung

  1. temperatureAfter cooling
  2. customthe reaction mixture was partitioned between ethyl acetate and saturated sodium bicarbonate solution
  3. dry with materialThe ethyl acetate solution was dried over sodium sulphate
  4. filtrationfiltered
  5. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-66268a2e9b0548628bb48820715b8d78
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08148373B2

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