Ammonia → 2-(3-(1-Oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-5-fluorophenyl)ethanol

HRID 1689337Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1689337
N.[F:2][C:3]1[CH:4]=[C:5]([CH:31]=[C:32]([CH2:34][CH2:35][OH:36])[CH:33]=1)[CH2:6][N:7]1[CH2:30][CH2:29][C:10]2([O:15][CH2:14][CH2:13][N:12](C(C3N=C(C4C=CC=CC=4)SC=3)=O)[CH2:11]2)[CH2:9][CH2:8]1>CO>[O:15]1[C:10]2([CH2:29][CH2:30][N:7]([CH2:6][C:5]3[CH:31]=[C:32]([CH2:34][CH2:35][OH:36])[CH:33]=[C:3]([F:2])[CH:4]=3)[CH2:8][CH2:9]2)[CH2:11][NH:12][CH2:13][CH2:14]1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 57989277(9-(3-Fluoro-5-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-phenylthiazol-4-yl)methanone

Produkt 1

HCID 579889902-(3-(1-Oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-5-fluorophenyl)ethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

‘880’ Ammonia solution (5 mL) was added to a solution of 2,2,2-trifluoro-1-(9-(3-fluoro-5-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)ethanone (example 41, step d) (2.2 g) in methanol (25 mL). The resulting mixture was stirred for 90 min and the solvent evaporated. The residue was azeotroped three times with acetonitrile and concentrated to give the subtitled compound as a clear gum. Yield 1.96 g.

Aufarbeitung

  1. customthe solvent evaporated
  2. customThe residue was azeotroped three times with acetonitrile
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-bcea76dbba3b452482729b2d45e4d07e
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08148373B2

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