Hydrochloric Acid → Ethyl 2-cyclobutylthiazole-4-carboxylate

HRID 1689348

Reaktionsgleichung

Reaktionsgleichung von HRID 1689348
Cl.[CH:2]1([C:6]([NH:8][CH:9]([CH2:15][SH:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=O)[CH2:5][CH2:4][CH2:3]1>C(O)C>[CH:2]1([C:6]2[S:16][CH:15]=[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:8]=2)[CH2:5][CH2:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 57989145Ethyl 2-(cyclobutanecarboxamido)-3-mercaptopropanoate

Produkt 1

HCID 54513950Ethyl 2-cyclobutylthiazole-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of HCl (4M in 1,4-dioxane, 3.46 mL) was added to a solution of ethyl 2-(cyclobutanecarboxamido)-3-mercaptopropanoate (example 58, step a) (3.2 g) in ethanol (20 mL) and the resulting mixture stirred overnight. The solvent was evaporated and the residue azeotroped twice with toluene. The residue was redissolved in acetonitrile (50 mL), manganese dioxide (12 g) was added and the mixture heated at reflux overnight. The reaction was filtered through a pad of Celite which was then washed with MeCN (3×100 mL). The combined filtrate and washings were evaporated and the residue was purified by silica gel chromatography eluting with 9:1 isohexane:ethyl acetate. The fractions containing product were combined and evaporated to give the subtitled compound as a clear oil. Yield 0.48 g.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe residue azeotroped twice with toluene
  3. dissolutionThe residue was redissolved in acetonitrile (50 mL)
  4. additionmanganese dioxide (12 g) was added
  5. temperaturethe mixture heated
  6. temperatureat reflux overnight
  7. filtrationThe reaction was filtered through a pad of Celite which
  8. washwas then washed with MeCN (3×100 mL)
  9. customThe combined filtrate and washings were evaporated
  10. customthe residue was purified by silica gel chromatography
  11. washeluting with 9:1 isohexane
  12. additionThe fractions containing product
  13. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-de4b2a20c1dd4864b64ad01eace15f72
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08148373B2

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