2-(4-Chloro-3-(hydroxymethyl)phenyl)ethanol → 2-Chloro-5-(2-hydroxyethyl)benzaldehyde

HRID 1689358

Reaktionsgleichung

Reaktionsgleichung von HRID 1689358
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][OH:10])=[CH:4][C:3]=1[CH2:11][OH:12]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][OH:10])=[CH:4][C:3]=1[CH:11]=[O:12]

Komponenten

4

Edukt 1

HCID 579892912-(4-Chloro-3-(hydroxymethyl)phenyl)ethanol

Produkt 1

HCID 579893312-Chloro-5-(2-hydroxyethyl)benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Manganese (IV) dioxide (1.00 g) was added to a solution of 2-(4-chloro-3-(hydroxymethyl)phenyl)ethanol (example 61, step b) (0.200 g) in DCM (5 mL), and the resulting suspension was stirred at room temperature overnight. The mixture was then filtered through Celite, washing the residue well with DCM. The filtrate and washings were concentrated in vacuo to afford the subtitled compound as a colourless oil. Yield 0.197 g.

Aufarbeitung

  1. filtrationThe mixture was then filtered through Celite
  2. washwashing the residue well with DCM
  3. concentrationThe filtrate and washings were concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6185c93af1964385aa4a3a50e2ca0c88
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08148373B2

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