4-Methyl-2-oxovaleric acid → Methyl 4-methyl-2-oxopentanoate

HRID 1689750Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1689750
[CH3:1][CH:2]([CH3:9])[CH2:3][C:4](=[O:8])[C:5]([OH:7])=[O:6].Cl[Si](C)(C)[CH3:12]>CO.COC(OC)(C)C>[CH3:12][O:6][C:5](=[O:7])[C:4](=[O:8])[CH2:3][CH:2]([CH3:9])[CH3:1]

Komponenten

5

Edukt 2

HCID 704-Methyl-2-oxovaleric acidHCID 6397Chlorotrimethylsilane

Produkt 1

HCID 546077Methyl 4-methyl-2-oxopentanoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 64952,2-DimethoxypropaneLösungsmittel

Versuchsvorschrift

To a solution of 4-methyl-2-oxo-pentanoic acid (3.4 g, 26 mmol) in methanol (12 mL) and 2,2-dimethoxypropane (48 mL) is added chlorotrimethylsilane (0.38 mL). The reaction mixture is stirred at ambient temperature overnight. The reaction mixture is concentrated under reduced pressure to give the title compound as an oil, (3.8 g, quant.). 1H NMR (400 MHz, CDCl3): δ 3.86 (s, 3H), 2.72 (d, 2H), 2.16 (m, 1H), 0.96 (d, 6H).

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bcf4c942452542b2835469abebe17bbc
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08153624B2

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