Skatole → 1,7-Dimethyl-1H-indole

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Reaktionsgleichung

[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[CH:7]2.[CH3:11]C1C2C(=CC=CC=2)NC=1>>[CH3:11][N:9]1[C:10]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[CH3:1])[CH:7]=[CH:8]1

Komponenten

Edukt 2

HCID 6736Skatole

HCID 702757-Methylindole

Produkt 1

HCID 5893901,7-Dimethyl-1H-indoleAusbeute 90 %

Versuchsvorschrift

According to the procedure of Preparation 13 (a), except substituting 7-methylindole for the 3-methylindole, the title compound (1.95 g, 90%) was obtained as a light-colored oil: MS (ES) m/e 146.2 (M+H)+.

Quellen und Nachweise

ORD-Eintrag: ord-eb0fa27c3cde42dc945fb664b383e6dd
Quelldatensatz: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08153652B2

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