HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → 1-[5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-1-(3-ethoxy-phenyl)-urea
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | Cyclohexyl isocyanate | HCID 18502 | — |
| Edukt | [5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-(3-ethoxy-phenyl)-amine | HCID 66905404 | — |
| Lösungsmittel | 1,2-Dichloroethane | HCID 11 | — |
| Produkt | 1-[5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-1-(3-ethoxy-phenyl)-urea | HCID 45111328 | — |
Reaktionsschritte
In analogy to the procedure described in example 1.2, [5-chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-(3-ethoxy-phenyl)-amine was reacted with cyclohexylisocyanate ([3173-53-3]) in 1,2-dichloroethane in the presence of Et3N (3 eq.) for 4 days under reflux conditions to give the title compound as colorless foam. MS: m/e=523.3 [M+H+].
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08153663B2 |
| Quelldatensatz | uspto-grants-2012_04 |
| ORD ID | ord-527921a53d2e412c9dffc5861238d93c |
| Quellennotiz | uspto-grants-2012_04 |