HCID 57652073, Verbindung → HCID 57652026, Verbindung

HRID 1691863Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1691863
[C:1](OC(N1CC[C@H](NC2C=CC(N)=CN=2)C1)=O)(C)(C)C.[CH3:21][O:22][C:23]([C@@H:25]1[CH2:29][CH2:28][C@H:27]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][N:32]=2)[CH2:26]1)=[O:24].COC([C@@H]1CC[C@H](NC2C=CC([N+]([O-])=O)=CN=2)C1)=O>>[CH2:21]([O:22][C:23]([C@@H:25]1[CH2:29][CH2:28][C@H:27]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][N:32]=2)[CH2:26]1)=[O:24])[CH3:1]

Komponenten

4

Edukt 3

HCID 57652073HCID 57652073, VerbindungHCID 66738250HCID 66738250, VerbindungHCID 66738402HCID 66738402, Verbindung

Produkt 1

HCID 57652026HCID 57652026, Verbindung

Versuchsvorschrift

With a method similar to that used for the preparation of (S)-3-(5-amino-pyridin-2-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester above, (1R,3S)-3-(5-amino-pyridin-2-ylamino)-cyclopentanecarboxylic acid methyl ester was prepared by the hydrogenation of (1R,3S)-3-(5-nitro-pyridin-2-ylamino)-cyclopentanecarboxylic acid methyl ester. This material was directly used in the next step without further purification.

Aufarbeitung

  1. customThis material was directly used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-33f4887b9d49421089b337bea53c504d
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08153644B2

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