Hydrogen Peroxide → 5-Amino-1-cyclohexyl-1H-pyrazole-4-carboxamide

HRID 1692728Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1692728
[OH:1]O.[NH2:3][C:4]1[N:8]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[N:7]=[CH:6][C:5]=1[C:15]#[N:16]>C(O)C.N>[NH2:3][C:4]1[N:8]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[N:7]=[CH:6][C:5]=1[C:15]([NH2:16])=[O:1]

Komponenten

5

Edukt 2

HCID 784Hydrogen PeroxideHCID 6900055-Amino-1-cyclohexyl-1H-pyrazole-4-carbonitrile

Produkt 1

HCID 179603635-Amino-1-cyclohexyl-1H-pyrazole-4-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 222AmmoniaLösungsmittelHCID 702EthanolLösungsmittel

Versuchsvorschrift

18 ml of 30% strength hydrogen peroxide solution are added to a solution of 5-amino-1-cyclohexyl-1H-pyrazole-4-carbonitrile (1.86 g, 9.81 mmol) in a mixture of 73 ml of ethanol and 90 ml of concentrated aqueous ammonia solution at room temperature, and the mixture is stirred at room temperature for 1 h. The nonaqueous solvents are then stripped off in a rotary evaporator. The product precipitates as solid from the remaining mixture and is filtered off with suction, washed with a little water and dried under high vacuum.

Aufarbeitung

  1. customThe nonaqueous solvents are then stripped off in a rotary evaporator
  2. customThe product precipitates as solid from the remaining mixture
  3. filtrationis filtered off with suction
  4. washwashed with a little water
  5. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-2ca2c52007304809a0b582a6ef655434
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08158633B2

Notizen zur Reaktion

Wird geladen…