1-(Trimethylsilyl)prop-1-yne → 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-trimethylsilanyl-1H-[1,2,3]triazole

HRID 1694513

Reaktionsgleichung

Reaktionsgleichung von HRID 1694513
[N:1]([CH:4]1[CH2:13][CH2:12][C:7]2([O:11][CH2:10][CH2:9][O:8]2)[CH2:6][CH2:5]1)=[N+:2]=[N-:3].[CH3:14][Si:15]([CH3:20])([CH3:19])[C:16]#[C:17]C>>[O:11]1[C:7]2([CH2:6][CH2:5][CH:4]([N:1]3[CH:17]=[C:16]([Si:15]([CH3:20])([CH3:19])[CH3:14])[N:3]=[N:2]3)[CH2:13][CH2:12]2)[O:8][CH2:9][CH2:10]1

Komponenten

3

Edukt 2

HCID 803631-(Trimethylsilyl)prop-1-yneHCID 574240948-Azido-1,4-dioxaspiro[4.5]decane

Produkt 1

HCID 577954251-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-trimethylsilanyl-1H-[1,2,3]triazoleAusbeute 105 %

Versuchsvorschrift

A mixture of 8-Azido-1,4-dioxa-spiro[4.5]decane (1.00 g, 5.43 mmol) and 1-(trimethylsilyl)propyne (3.76 mL, 27.1 mmol) was submitted to microwave at 120° C. for 2 h. The mixture was concentrated under vacuum to remove the excess of 1-(trimethylsilyl)propyne and crude 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-trimethylsilanyl-1H-[1,2,3]triazole (1.6 g, 105%) was obtained.

Aufarbeitung

  1. concentrationThe mixture was concentrated under vacuum
  2. customto remove the excess of 1-(trimethylsilyl)propyne

Quellen und Nachweise

ORD-Eintrag
ord-3f4a0932261f4295845f2833878ea275
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08158675B2

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